CSIG-29. EMPLOYING THE ZIKA VIRUS AS ONCOLYTIC VIROTHERAPY AGAINST PAEDIATRIC NERVOUS SYSTEM CANCER CELLS
نویسندگان
چکیده
Abstract BACKGROUND Malignant paediatric nervous system tumours, such as medulloblastoma, ATRT and high-risk neuroblastoma commonly harbour tumour cells with stem-like features which are highly tumorigenic resistant to conventional therapies. These tumours can exhibit high lethality may result in severe sequelae that significantly affect patients' quality of life. Oncolytic virotherapy exploits viruses preferentially infect destroy cells. present a unique advantage targeting heterogeneous cancers they possess secondary mechanism action, through induce an anti-tumoral immune response. The Zika virus (ZIKV) is capable infecting destroying aggressive human brain vitro. ZIKV effectively reduces size mice (xenograft model) canines (naturally occurring) response against canine tumours. METHODS Employing global expression omics profiling infection mapping viral protein-host protein interactions, we aim elucidate the mechanisms underpin ZIKVs therapeutic properties, both at molecular cellular pathway levels. RESULTS Through extensive transcriptome ZIKV-infected tumour, NPCs, have identified variety pathways involved oncolytic its neuro-dysregulation NPCs. Despite undergoing ZIKV-induced oncolysis, observed there be within these different level lead oncolysis. Additionally, infected demonstrate elevated profiles alludes raise patient’s body tumour. Analysing our findings alongside observe NPCs allowing us build safety profile for employing ZIKV-based therapy, whilst contributing growing knowledge Congenital Syndrome.
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac209.178